Effect of Hypophysectomy on the Cytology of the Fundic Glands of the Stomach and on the Secretion of Pepsin

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Abstract
Hypophysectomy of rats caused a severe involution of the gastric zymogenic cells which was accompanied by loss of pepsinogen granules and cytoplasmic ribonucleic acid. Similarly, there was a loss in capacity to secrete pepsin. These changes were present 3 days after the operation and were maintained for the period of study of 128 days. Seven days after hypophysectomy the capacity to secrete pepsin was reduced 80%. Parietal cells were smaller and less granulated. The mucus content of the surface and pit epithelium and of the mucous neck cells was not reduced. Argentophile cells showed little change.