Conversion of acetate to lipids and CO2 by liver of rats exposed to acceleration stress

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Abstract
Male Sprague-Dawley rats in age groups from 1 to 20 weeks were centrifuged at 4.5 g for periods of 0.5 hr-14 days. Slices of liver, kidney, and inguinal adipose tissue were incubated with C14-labeled acetate, and the resulting isotopic CO2 and lipids were measured. When compared with tissues from control rats, liver and adipose tissue from nonfasted centrifuged rats showed increased formation of C14-labeled lipids while kidney showed a decrease. Liver from fasted centrifuged rats also showed increased formation of C14-labeled lipids when compared to fasted noncentrifuged controls. The increase in acetate conversion to lipids varied with age of animal and duration of exposure to acceleration. No significant change in acetate-C14 oxidation to C14O2 by liver was noted in either fed or fasted centrifuged animals as compared to their corresponding controls. The total lipid content of liver from rats that were exposed to centrifugation was lower than that from control animals.

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