Hemodynamic, Hormonal, and Renal Effects of Intracerebroventricular Adrenomedullin in Conscious Sheep

Publisher Website
Google Scholar
Abstract
Adrenomedullin, the recently described vasodilator that exhibits potent hypotensive actions when administered systemically, is also found in the central nervous system, suggesting a role for ad- renomedullin as a neurohormone. However, only a limited number of studies have examined the central effects of adrenomedullin. There- fore, we have examined the integrative hemodynamic, renal, and hormonal effects of intracerebroventricular (ICV) adrenomedullin in conscious sheep. Eight surgically prepared sheep received ICV infu- sions of adrenomedullin at two doses (2 ng/kgzmin followed immedi- ately by 20 ng/kgzmin each for 90 min) in a vehicle-controlled study. Water deprivation for 48 h before control infusion resulted in sheep drinking 2617 6 583 ml in the 90-min period following reintroduction

This publication has 0 references indexed in Scilit: