ASYMMETRIC SYNTHESIS OF 3-ALKYLSUCCINALDEHYDIC ACID METHYL ESTERS
- 5 May 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 8 (5) , 569-572
- https://doi.org/10.1246/cl.1979.569
Abstract
The highly stereoselective Michael addition was achieved by treating an aminal, prepared from (S)-2-(anilinomethyl)pyrrolidine and fumaraldehydic acid methyl ester, with the Grignard reagents. 3-Alkylsuccinaldehydic acid methyl esters were obtained with high enantiomeric excesses by the hydrolysis of the resulting aminals.Keywords
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