Reduction of Blood Pressure by Puromycin Infused Selectively into the Ischaemic Kidney in Experimental Renal Hypertension
- 1 July 1967
- journal article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 1 (3) , 215-218
- https://doi.org/10.1093/cvr/1.3.215
Abstract
In rats made hypertensive by unilateral renal artery constriction, blood pressure could be reduced to normal levels or below by infusion, into the aorta near the origin of the renal arteries, of a solution of puromycin, an inhibitor of protein synthesis. Identical infusions into normal rats, or infusions into hypertensive rats below the origin of the renal arteries, produced no such effect.Keywords
This publication has 7 references indexed in Scilit:
- The Influence of Arterial Pressure on the Antihypertensive Action of a Normal Kidney, a Biological ServomechanismAnnals of Internal Medicine, 1964
- An Evaluation of Treatment of Hypertension Associated with Occlusive Renal Arterial DiseaseCirculation, 1963
- Relationship of Juxtaglomerular Apparatus to Renin and AngiotensinCirculation, 1962
- Effect of puromycin in vivo on the synthesis of protein, RNA and phospholipids in rat tissuesArchives of Biochemistry and Biophysics, 1961
- INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEINProceedings of the National Academy of Sciences, 1959
- Increased Renal Pressor Activity (Renin) in Sodium Deficient Rats and Correlation with Juxtaglomerular Cell Granulation.Experimental Biology and Medicine, 1959
- Pressor Substances in Kidneys of Renal Hypertensive Rats with and Without AdrenalsExperimental Biology and Medicine, 1958