Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity
- 1 September 2003
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 13 (17) , 2895-2898
- https://doi.org/10.1016/s0960-894x(03)00623-1
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action CascadeJournal of Biological Chemistry, 2001
- Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B GeneScience, 1999
- Vanadium Compounds: Biological Actions and Potential as Pharmacological AgentsTrends in Endocrinology & Metabolism, 1997
- Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjectsDiabetes, 1996
- Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB ratsDiabetes, 1995
- Purification, identification and subcellular distribution of three predominant protein-tyrosine phosphatase enzymes in skeletal muscle tissueBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1995
- Insulin mimetic peroxovanadium complexes: preparation and structure of potassium oxodiperoxo(pyridine-2-carboxylato)vanadate(V), K2[VO(O2)2(C5H4NCOO)].2H2O, and potassium oxodiperoxo(3-hydroxypyridine-2-carboxylato)vanadate(V), K2[VO(O2)2(OHC5H3NCOO)].3H2O, and their reactions with cysteineInorganic Chemistry, 1993
- A thousand and two protein tyrosine phosphatasesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1992
- Protein‐Tyrosine phosphatases and the regulation of insulin actionJournal of Cellular Biochemistry, 1992
- Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane EnzymesScience, 1991