Renin substrates. Part 1. Liquid-phase synthesis of the equine sequence with benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP)

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Abstract
The tetradecapeptide Ac-Asp1-Arg2-Val3-Tyr4-lle5-His6-Pro7-Phe8-His9-Leu10-Leu11-Val12-Tyr13-Ser14-OH has been synthesized by a three-segment coupling strategy. All the coupling steps were carried out with benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent). Histidine was incorporated in good yield by using Boc(Nim-Boc)histidine (DCHA).