The Effect of Parenteral Feeding on the Postoperative Protein Metabolism

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Abstract
The changes in the postoperative excretion of certain products of protein metabolism: creatine, uric acid, proline, hydroxyproline and amino N in starving and in adequately fed patients was studied. The catabolic reaction of the muscle and cell nucleus was most marked in the starving patients. The increased creatine and uric acid excretion which occurs after administration of amino acid preparations can be regarded as a catabolic reaction of the great amount of amino acids. In certain amino acid preparations there is a lot of ineffective peptide. One can only get reliable information about the N balance by the joint determination of total N and amino N. The catabolic reaction of the connective tissue is the most pronounced in starving patients. The reaction of the connective tissue to trauma is only diminished by the intake of calories. The increased hydroxyproline formation after the administration of amino acids may favorably influence wound healing.