Cocaine-Induced Rotation: Sex-Dependent Differences Between Left- and Right-Sided Rats
- 19 August 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4612) , 775-777
- https://doi.org/10.1126/science.6879177
Abstract
Cocaine elicited dose-related rotation (circling) in naïve rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results suggest that sex-dependent differences in brain asymmetry may be an important determinant of cocaine sensitivity.This publication has 34 references indexed in Scilit:
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