The Chemical Inhibition of the Repair of Single-strand Breaks in DNA: Post-irradiation Sensitization to X-rays
- 1 January 1971
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 19 (3) , 255-262
- https://doi.org/10.1080/09553007114550361
Abstract
A class of radiosensitizers is discussed which irreversibly inhibits the repair of x-ray-induced single-strand breaks in DNA. Such agents are active when added after irradiation and potentiate x-ray-induced killing in rec+ strains of E. coli K-12, but have little effect on the viability of x-irradiated recA strains which are deficient in their ability to repair x-ray-induced single-strand breaks. Chromatographically-impure samples of hydroxyurea (but not pure samples) have the properties associated with this class of post-irradiation sensitizers.Keywords
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