Regulation and pro‐inflammatory function of interleukin‐17 family cytokines
- 30 October 2008
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 226 (1) , 80-86
- https://doi.org/10.1111/j.1600-065x.2008.00709.x
Abstract
Summary: The interleukin‐17 (IL‐17) family consists of six cytokines in mammals. Among them, IL‐17 and IL‐17F are expressed by a novel subset of CD4+ helper T cells and play critical function in inflammation and autoimmunity. IL‐17E, also called IL‐25, has been associated with allergic responses. Here, I summarize recent work by my laboratory as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL‐17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.Keywords
This publication has 81 references indexed in Scilit:
- Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell ProgramsPublished by Elsevier ,2008
- TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt functionNature, 2008
- T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγImmunity, 2008
- IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC–activated Th2 memory cellsThe Journal of Experimental Medicine, 2007
- Interleukin 25 promotes the initiation of proallergic type 2 responsesThe Journal of Experimental Medicine, 2007
- Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expressionProceedings of the National Academy of Sciences, 2007
- Selective regulatory function of Socs3 in the formation of IL-17-secreting T cellsProceedings of the National Academy of Sciences, 2006
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006
- Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsionThe Journal of Experimental Medicine, 2006
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainNature, 2003