FACTORS INFLUENCING THE NUTRITIONAL VALUE OF FISH FLOUR: V. CHLOROCHOLINE CHLORIDE, A TOXIC MATERIAL IN SAMPLES EXTRACTED WITH 1,2-DICHLOROETHANE

1 July 1967

journal article
research article
Published by Canadian Science Publishing in Canadian Journal of Biochemistry

Vol. 45 (7) , 1049-1053
https://doi.org/10.1139/o67-121

Abstract

Extraction of lyophilized cod fillets with 1,2-dichloroethane resulted in the formation of chloro-choline chloride (CCC) (2-chloroethyl)trimethylammonium chloride), a toxic choline derivative. CCC isolated chromatographically from 1,2-dichloroethane-extracted fish was identical with CCC prepared by reacting 1,2-dichloroethane with trimethylamine. The infrared spectrum of the reineckate salt of CCC isolated from 1,2-dichloro-ethane-extracted fish also was found to be identical with synthetic chlorocholine reineckate. A method for the determination of CCC in 1,2-dichloroethane-extraced fish is described.

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