METABOLISM OF 1,1,1-TRICHLORO-2,2-BIS(PARA-CHLOROPHENYL)ETHANE (DDT), 1,1-DICHLORO-2,2-BIS(PARA-CHLOROPHENYL)ETHANE, AND 1-CHLORO-2,2-BIS(PARA-CHLOROPHENYL)ETHENE IN THE HAMSTER

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (6) , 2644-2647
Abstract
The urinary metabolites of DDT, DDD and 1-chloro-2,2-bis(p-chlorophenyl)ethene in female hamsters are reported. The principal metabolite of both DDT and DDD is 2,2-bis(p-chlorophenyl) acetic acid. DDT- and DDD-treated animals also excreted small amounts of DDD, 1-chloro-2,2-bis(p-chlorophenyl)ethene,1,1-dichloro-2,2-bis(p-chlorophenyl)ethene, 2-hydroxy-2,2-bis(p-chlorophenyl)acetic acid, and 2,2-bis(p-chlorophenyl)ethanol. 1-Chloro-2,2-bis(p-chlorophenyl)ethene is metabolized to afford significant amounts of 2,2-bis(p-chlorophenyl)acetic acid, 2,2-bis(p-chlorophenyl)ethanol, 2-hydroxy-2,2-bis(p-chlorophenyl)acetic acid, 2,2-bis(p-chlorophenyl)acetaldehyde, and 1,1-bis(p-chlorophenyl)ethan-1,2-diol. The metabolic disposition of DDT in the hamster, a species refractory to DDT tumorigenicity, is very similar to that observed previously in the mouse, a species sensitive to DDT tumorigenicity. The one exception is that the hamster is not nearly as efficient as the mouse in converting DDT to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethene, a metabolite that is tumorigenic in both species.

This publication has 1 reference indexed in Scilit: