Susceptibility of Aspergillus to 5-fluorocytosine and amphotericin B alone and in combination

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Abstract
We report the in vitro activity of amphotericin B and 5-fluorocytosine alone and in combination against 7 strains of Aspergillus fumigatus and 6 strains of A. niger. Susceptibility tests were done with yeast nitrogen base agar by the agar dilution method. With 5-fluorocytosine 8 strains had MICs≥1μg/ml, 4 strains had MICs≤128 μg/ml, and 1 strain of A. niger gave inconsistent results on repeated testing. When compared to growth in control tubes of antimicrobial-free medium, each strain was partially inhibited at 24 to 36 h by ≥0.12 μg/ml of 5-fluorocytosine. Amphotericin B inhibited all 13 strains at 2 μg or less per ml. The combined activity of the 2 drugs was no greater than the activity of either drug alone; neither synergism nor antagonism was demonstrated against any isolate. Nonetheless, further study of the activity of 5-fluorocytosine and amphotericin B against Aspergillus species isolated from human infections is warranted.

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