Sulfhydryl Compounds May Mediate Gastric Cytoprotection
- 9 October 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 214 (4517) , 200-202
- https://doi.org/10.1126/science.7280691
Abstract
Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2 beta. These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.This publication has 16 references indexed in Scilit:
- The Surgical Management of Bleeding Stress UlcersAnnals of Surgery, 1980
- High Concentrations of Glutathione in Glandular Stomach: Possible Implications for CarcinogenesisScience, 1979
- Pathogenesis of Experimental Gastric-Mucosal InjuryNew England Journal of Medicine, 1979
- Gastrointestinal cytoprotection by prostaglandins.Gut, 1979
- PHARMACOLOGY OF MUCUSBritish Medical Bulletin, 1978
- The Glutathione Status of CellsPublished by Elsevier ,1978
- Glutathione dependent control of protein disulfide-sulfhydryl content by subcellular fractions of hepatic tissueBiochimica et Biophysica Acta (BBA) - General Subjects, 1977
- A sensitive method for localization of disulfide containing peptides in column effluentsAnalytical Biochemistry, 1973
- Coupling of a measuring eyepiece to a voltage divider to allow the continuous display of measured microscopic dimensionsAnalytical Biochemistry, 1968
- Multiple Comparisons Using Rank SumsTechnometrics, 1964