The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine
- 1 March 1996
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Medicine
- Vol. 74 (3) , 143-147
- https://doi.org/10.1007/bf01575446
Abstract
The treatment of chronic lymphocytic leukemia includes the use of alkylating agents, steroids, and more recently nucleoside analogues. While prior studies have described potential mechanisms of 2-chlorodeoxyadenosine cytotoxicity including the accumulation of DNA strand breaks and induction of apoptosis or programmed cell death, the expression of p53 and its downstream target WAF1/CIP1 have not been examined. In this report we describe the induction of p53 and WAF1/CIP1 in the apoptotic chronic lymphocytic leukemia cells after exposure to 2-chlorodeoxyadenosine.Keywords
This publication has 17 references indexed in Scilit:
- A Selective Procedure for DNA Extraction from Apoptotic Cells Applicable for Gel Electrophoresis and Flow CytometryAnalytical Biochemistry, 1994
- Clinical Experience with Fludarabine in LeukaemiaDrugs, 1994
- The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesCell, 1993
- WAF1, a potential mediator of p53 tumor suppressionCell, 1993
- p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsCell, 1993
- p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.Proceedings of the National Academy of Sciences, 1991
- Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.Proceedings of the National Academy of Sciences, 1984
- Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cellsCell, 1982
- Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cellsCell, 1979
- The treatment of chronic lymphocytic leukemia with COP chemotherapyCancer, 1978