PRIMARY AND SECONDARY ABNORMALITIES OF T-CELL SUB-POPULATIONS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 34  (3) , 388-392
Abstract
Ataxia telangiectasia patients had normal numbers of T [thymus-derived] lymphocytes in their blood but Ig[immunoglobulin]M-binding T lymphocytes (TM) were selectively reduced. These changes provide a cellular basis for the defects in cell-mediated immunity which occur in this primary condition. One child with severe combined immunodeficiency lacked TM and IgG-binding (TG) T lymphocytes, but no consistent abnormalities of T cell subsets were found in other primary immunodeficiency syndromes. Secondary increases in IgG-binding T lymphocytes (TG) were found in children receiving steroids.