CO2 Retention in Anesthetized Dogs after Inhibition of Carbonic Anhydrase.

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Abstract
Injection of the carbonic anhydrase inhibitor, acetazolamide, produced a temporary reduction of CO2 elimination in anesthetized dogs. The reduction was greater in dogs whose ventilation was held constant than in dogs which were allowed to ventilate spontaneously. The results indicate that an increased gradient of CO2 partial pressure from tissues to alveolar gas is essential for re-establishment of a steady state of CO2 elimination in the presence of carbonic anhydrase inhibition. The necessary increase in this gradient can be produced by an increase in ventilation, by a rise in tissue PCO2, or by a combination of these two factors.

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