The Effect of Thalidomide in Experimental Gastric Ulcers

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Abstract
A study has been made of the effects of thalidomide, a new sedative hypnotic drug, in stress and phenylbutazone-induced ulcers in the rat. The results have shown that thalidomide inhibits stress induced ulcers but does not affect the local mechanisms involved in the pathogenesis of phenylbutazone-induced ulcers. It does eliminate stress-induced components in phenylbutazone ulcers, which indicates that the mode of action is a central one.

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