Synthesis and Characterization of a Doxorubicin−Gd(III) Contrast Agent Conjugate: A New Approach toward Prodrug−Procontrast Complexes
- 22 September 2006
- journal article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 45 (21) , 8489-8491
- https://doi.org/10.1021/ic0612045
Abstract
We have prepared the first MRI prodrug−procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.Keywords
This publication has 13 references indexed in Scilit:
- Three in One: TSA, TSA‘, and SA Units in One Crystal Structure of a Yttrium(III) Complex with a Monophosphinated H4dota AnalogueInorganic Chemistry, 2006
- A Gadolinium Chelate for Detection of β-Glucuronidase: A Self-Immolative ApproachJournal of the American Chemical Society, 2005
- Dinuclear, Bishydrated GdIII Polyaminocarboxylates with a Rigid Xylene Core Display Remarkable Proton RelaxivitiesInorganic Chemistry, 2005
- A Tris-hydroxymethyl-Substituted Derivative of Gd-TREN-Me-3,2-HOPO: An MRI Relaxation Agent with Improved EfficiencyJournal of the American Chemical Society, 2000
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinBiochemical Pharmacology, 1999
- A holmium complex of a macrocyclic ligand (DOTA) and its isostructural europium analogueActa Crystallographica Section C Crystal Structure Communications, 1999
- A “Smart” Magnetic Resonance Imaging Agent That Reports on Specific Enzymatic ActivityAngewandte Chemie International Edition in English, 1997
- Structural and Dynamic Parameters Obtained from 17O NMR, EPR, and NMRD Studies of Monomeric and Dimeric Gd3+ Complexes of Interest in Magnetic Resonance Imaging: An Integrated and Theoretically Self-Consistent Approach1Journal of the American Chemical Society, 1996
- (6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicinBioconjugate Chemistry, 1993
- Antibody conjugates with morpholinodoxorubicin and acid cleavable linkersBioconjugate Chemistry, 1990