Biochemical Effects of Oxygen at High Pressure in Rats

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Abstract
Changes in brain and muscle lactate dehydrogenase, cytochrome oxidase, and NADH dehydrogenase (cytochrome c reductase) have been measured in rats convulsed by exposure to oxygen at high pressure 6 ATA (OHP). Blood glucose levels and some plasma and serum enzymes (lactate dehydrogenase, alkaline phosphatase, aspartate transaminase, and creatine kinase) were measured simultaneously. The lack of widespread inhibition of several markers for the glycolytic sequence, the Krebs cycle, or the cytochrome chain, together with elevated blood glucose levels in hyperoxia and increased blood alkaline phosphatase and lactate dehydrogenase in all hyperbaric conditions (and as well as oxygen), suggests tissue damage and a generalized etiology for the convulsive state.

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