Transepidermal water loss and sweat gland response in lamellar ichthyosis before and during treatment with etretinate: report of three cases

Abstract
Despite its desquamative effect, oral etretinate had no normalizing effect on the increased basal transepidermal water loss in 3 patients with lamellar ichthyosis. Neither was any improvement achieved during treatment in the defective sweat gland function as measured after stimulation by intracutaneously injected methacholine chloride solution.

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