Increased G+C content of DNA stabilises methyl CpG dinucieotides
Open Access
- 25 July 1984
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (14) , 5869-5877
- https://doi.org/10.1093/nar/12.14.5869
Abstract
The vertebrate genome is a mosaic of regions differing dramatically in their G+C content. Those regions with a high G+C Content contain the expected number of CpG dinucleotides and we propose that following rnethylation these have been protected from deamination by the increased stability of the surrounding DNA duplex. This argument applies both to the microenvironment of the CpG dinucleotide and to whole gene regions.Keywords
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