EXPERIENCES IN A DOUBLE-BLIND-STUDY WITH DIFFERENT CONCENTRATIONS OF TIMOLOL AND PILOCARPINE

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 177  (4) , 443-450
Abstract
Fifty patients with chronic open-angle glaucoma were studied in a double-blind study with timolol ophthalmic solution, in a concentration of 0.1, 0.2 and 0.5%, and pilocarpine eye drops 1, 2 and 4% over a period of 17 wk. Timolol was instilled twice daily into the conjunctival sack, or pilocarpine 4 times daily. Timolol (0.1%-0.5%) achieved a moderate reduction in I.O.P. [intraocular pressure] of 29%, compared to a 10.3% drop with pilocarpine (1%-4%). Under treatment with timolol, there was a statistically significant reduction in pulse rate of 12%, and a slight drop in blood-pressure of 3.5% systolic and 2.5% diastolic. During this study, those treated with timolol showed no statistical changes of visual acuity, visual field or on slit lamp examination and ophthalmoscopy of the optic disk and retina. The average pupillary diameter and tear flow (Schirmer Test), were little changed in the group of patients treated with timolol, but in the pilocarpine group, the size of the pupil decreased by 30.5% as expected.

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