Oral polio vaccine. Effect of booster vaccination one to 14 years after primary series

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Abstract
The persistence of antibody after vaccination and the response to booster revaccination with trivalent oral polio vaccine (TOPV) administered at varied intervals after the primary series were studied in a large group of children. Decline in antibody was related to intervals since last vaccination and not to sex, age, age at primary vaccination or type and number of previous administrations. Geometric mean titers of neutralizing antibody were 11.3 for type 1 and 8.0 for types 2 and 3 poliovirus when vaccine was given within the previous year, declining to 3.2, 3.0 and 2.1 for types 1, 2 and 3 after 9 yr. Most children with an initial titer of 4 or less responded to revaccination with a 4-fold or greater increase in titer of Ig[immunoglobulin]G. Geometric mean titers for all 3 types of polio dropped to this level when last TOPV administration had been 5-6 yr or more.

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