The synthesis of mesoinositol in germ-free rats and mice

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Abstract
The biosynthesis of inositol from glucose has been examined in normal and germ-free rats and mice. After the acute intraperitoneal administration of [1-C14]glucose, [C14]inositol could be isolated from all animals. In paired germ-free and control rats and mice, the recoveries of radioactive inositol were of the same order of magnitude. The findings would indicate that inositol can be formed from glucose in these species and that endogenous biosynthesis does not require the presence of alimentary canal microorganisms.