EFFECTS OF BENZALKONIUM CHLORIDE UPON THE CORNEAL EPITHELIUM STUDIED WITH SCANNING ELECTRON MICROSCOPY
- 1 June 1975
- journal article
- Published by Wiley in Acta Ophthalmologica
- Vol. 53 (3) , 358-366
- https://doi.org/10.1111/j.1755-3768.1975.tb01167.x
Abstract
The corneal surface of rabbits and vervet monkeys was studied by means of scanning electron microscopy after the influence of the cationic surfactant, benzalkonium chloride. The concentration of the drug was 0.02% or 0.01% and the exposure time was 2 or 4 min. The corneas treated with the drug had characteristic changes with small holes or more extensive lesions of the superficial cell membranes, and loss of microvilli or microplicae. The damage was considered to be due to the lytic effect of benzalkonium chloride upon the plasma membranes.Keywords
This publication has 6 references indexed in Scilit:
- PERMEABILITY OF HORSERADISH PEROXIDASE IN THE RABBIT CORNEAL EPITHELIUMActa Ophthalmologica, 2009
- PERMEABILITY OF RABBIT CORNEAL EPITHELIUM TO HORSERADISH PEROXIDASE AFTER THE INFLUENCE OF BENZALKONIUM CHLORIDEActa Ophthalmologica, 1975
- Influence of Various Agents on Corneal PermeabilityAmerican Journal of Ophthalmology, 1971
- Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscopeJournal of Molecular Biology, 1964
- The effect of surface active agents on the permeability to dye of the plasma membrane of ehrlich ascites cellsExperimental Cell Research, 1960
- CARBAMINOYLCHOLINE CHLORIDE IN THE TREATMENT OF GLAUCOMA SIMPLEXArchives of Ophthalmology (1950), 1942