Tissue penetration and pharmacokinetics of lomefloxacin following multiple doses
- 1 February 1989
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 8 (2) , 168-170
- https://doi.org/10.1007/bf01963906
Abstract
The pharmacokinetics of lomefloxacin were studied after three days of oral administration of 400 mg/day lomefloxacin. Following the final dose the concentrations in serum, urine and cantharidin-induced inflammatory fluid were measured by a microbiological assay. The mean peak serum level was 4.9 mg/l at a mean time of 0.8 h. The mean serum elimination half-life was 6.2 h. The mean maximum inflammatory fluid level attained was 3.2 mg/l at 2.7 h. Urinary recovery accounted for the greater part of lome-floxacin's elimination.This publication has 11 references indexed in Scilit:
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