Alterations of Methionine to Cysteine Conversion Rates and Nutritional Muscular Dystrophy in Chicks.

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Abstract
Summary The effects of methionine-transmethylation metabolites on nutritional muscular dystrophy and methionine to cysteine conversion rates in vitamin E-deficient chicks have been studied. The results show that guanidoacetic acid accelerates the conversion of methionine to cysteine and reduces the severity of nutritional muscular dystrophy, and that creatine, choline and betaine inhibit that conversion and accentuate the dystrophy. Therefore cysteine, not methionine, must be the metabolically active sulfur amino acid in the prevention of nutritional muscular dystrophy in vitamin E-deficient chicks.

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