A Comparison of Alphaprodine and Meperidine Pharmacokinetics

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Abstract
A GLC analysis for measuring plasma alphaprodine was developed. The analysis is sufficiently sensitive for studying therapeutic-dose pharmacokinetics in man. Single i.v. bolus injections of either alphaprodine or meperidine were given to volunteer subjects. Plasma concentration data were fitted to a biexponential equation and pharmacokinetic parameters were calculated. Consistent with alphaprodine''s shorter clinical duration compared to meperidine, plasma levels of alphaprodine decline at a more rapid rate. Plasma clearances for the 2 narcotic analgesics are nearly identical (1.04 l/kg per min for alphaprodine and 1.01 l/kg per min for meperidine). The apparent volume of distribution for alphaprodine is smaller than for meperidine (1.90 l/kg for alphaprodine and 3.37 l/kg for meperidine).

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