The Initiation of Mast Cell Degranulation: Activation at the Cell Membrane
Open Access
- 1 March 1975
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 114 (3) , 966-970
- https://doi.org/10.4049/jimmunol.114.3.966
Abstract
The low molecular weight mast cell activator, polymyxin B, has been covalently bound to an insoluble matrix of Sepharose 4B. It has been demonstrated that mast cells in preparations of rat peritoneal cells bind to Sepharose 4B-polymyxin B beads but not to control beads. The bound cells are stimulated to degranulate by this interaction at the cell membrane with the resultant release of biogenic amines.Keywords
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