Effect of aspirin on platelet aggregation in diabetes mellitus

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Abstract
The effect of aspirin in vitro and in vivo on platelet aggregation has been studied in 13 diabetic subjects without retinopathy, 16 diabetic subjects with retinopathy and 20 ageand sex-matched control subjects. The rate, degree and duration of collagen-induced aggregation were greater in the diabetic patients (p < 0.05;p < 0.01;p < 0.05). The residual aggregation in vivo was greater in all diabetic patients with aspirin, whilst it only occurred in vitro in patients without retinopathy. A decreased latent period was seen in diabetic patients, to a greater extent in those with retinopathy. Significant differences in the rate, degree and duration of arachidonic acid-induced-aggregation were also seen in patients with retinopathy treated with aspirin (p < 0.05;p < 0.01;p < 0.05). Disaggregation only occurred with aspirin in vitro and was more frequently seen in normal subjects.