Could Valerian Have Been the First Anticonvulsant?
- 27 October 2004
- Vol. 45 (11) , 1338-1343
- https://doi.org/10.1111/j.0013-9580.2004.27904.x
Abstract
To assess the available evidence for the belief that valerian, highly recommended in the past for treating epilepsy, possessed real anticonvulsant effectiveness. Review of available literature. In 1592, Fabio Colonna, in his botanical classic Phytobasanos, reported that taking powdered valerian root cured his own epilepsy. Subsequent reports of valerian's anticonvulsant effectiveness appeared. By the late 18th and early 19th centuries, it was often regarded as the best available treatment for the disorder. Valerian preparations yield isovaleric acid, a substance analogous to valproic acid and likely to possess anticonvulsant properties, as isovaleramide does. In favorable circumstances, high valerian doses can be calculated to have sometimes provided potentially effective amounts of anticonvulsant substance for epilepsy patients. Valerian probably did possess the potential for an anticonvulsant effect, but the uncertain chemical composition and content of valerian preparations, and their odor and taste, made it unlikely that they could ever prove satisfactory in widespread use.Keywords
This publication has 7 references indexed in Scilit:
- New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?Current Opinion in Neurology, 2003
- Valeriana officinalisThe Journal of Alternative and Complementary Medicine, 2001
- Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V)Epilepsy Research, 2000
- The Scientific Basis for the Reputed Activity of ValerianJournal of Pharmacy and Pharmacology, 1999
- Clinical Pharmacology of ValpromideClinical Pharmacokinetics, 1991
- AN INQUIRY INTO THE EFFECTS OF THE PROLONGED ADMINISTRATION OF THE BROMIDES IN EPILEPSY.The Lancet, 1884
- ART. XXIX.???Lectures on Epilepsy, Pain, Paralysis, and certain other Disorders of the Nervous SystemThe Lancet Healthy Longevity, 1866