INFECTION OF CONGENITALLY ATHYMIC (NUDE) MICE WITH TOXOPLASMA-GONDII

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  • 1 January 1976
    • journal article
    • research article
    • Vol. B127  (4) , 503-507
Abstract
Nude mice, congenitally lacking most thymus-derived [T] lymphocytes, are not more susceptible or more resistant against primary infection with virulent T. gondii cells than normal control mice. Both mouse groups died at the same time after i.p. infection. Treatment with sulfadiazine protected both mouse groups against acute fatal disease. After termination of treatment with sulfadiazine the nude mice gradually died; the normal hairy mice survived. The latter developed high antibody titers and protective immunity to an otherwise lethal challenge infection. In the serum of nude mice no antibodies could be detected. Pathologic alterations existed in the livers of nude mice at the time of death.

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