The effect of estrogen on fetal survival in progesterone-treated ovariectomized rats.

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Abstract
In pregnant rats ovariectomized on Day 14 of pregnancy (sperm present = Day 1), the daily injection of 4 mg progesterone maintained normal pregnancy up to Day 17, but injured fetuses bearing hematomata on their extremities appeared very frequently thereafter, in spite of successive injections of progesterone. The addition of 0.2 .mu.g estradiol-17.beta. to the daily dose of progesterone for 2 successive days between Days 15 and 18 of pregnancy prevented the occurrence of fetal injuries. Estradiol-17.beta. was more effecti ve in preventing fetal damage than estrone or estriol. While progesterone is essential for the maintenance of pregnancy, estrogen apparently is also necessary at the time when the conceptus elongates and becomes cylindrical.

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