6,9-deepoxy-6,9-(phenylimino)-Δ6,8-Prostaglandin I1, (U-60, 257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells
Open Access
- 1 November 1984
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 83 (3) , 603-605
- https://doi.org/10.1111/j.1476-5381.1984.tb16213.x
Abstract
6,9-deepoxy- 6,9- (phenylimino)-Δ6,8-Prostaglandin I1 (U-60,257), a prostaglandin analogue known to inhibit leukotriene formation in a number of cell systems, potentiates mast cell release of prostaglandin D2 from human dispersed lung cells activated with ionophore A23187. Over the same concentration range of 30−300 μm there was a related inhibition of ionophore-induced generation of thromboxane B2 (r = 0.93, P < 0.01). As both prostaglandin D2 and thromboxane A2 are potent bronchoconstrictors, these observations may be relevant to the potential of this drug in the treatment of asthma.Keywords
This publication has 3 references indexed in Scilit:
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