STUDIES ON THE MECHANISM OF THE POTENTIATION OF CIRCULATORY EFFECTS OF HYPERTONIC SOLUTIONS RESULTING FROM ADMIXTURE OF THESE SOLUTIONS WITH HOMOLOGOUS BLOOD

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Abstract
When the blood of dogs or rabbits is mixed with strongly concentrated solns. of NaCl, and the formed elements subsequently resuspended in isotonic saline soln., a depressor substance is released from the cells. This substance has not been identified, but it is not K, acetyl-choline or histamine. It is suggested that this material, and a smooth muscle-inhibiting substance liberated from guinea pig erythrocytes in the same circumstances, may be similar to or identical with the adenosine-like compounds released from mammalian red blood cells under various exptl. conditions (shaking or clotting of blood, hemolysis, etc.). The release of this depressor material may account, at least in part, for the potentiation of the hypotensive effects of hypertonic solns. which results from admixture of such solns. with homologous blood.

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