CONTROL OF THE ACUTE-PHASE RESPONSE - C-REACTIVE PROTEIN-SYNTHESIS BY ISOLATED PERFUSED RABBIT LIVERS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 96  (6) , 1037-1045
Abstract
The synthesis of CRP [C-reactive protein] by perfused livers that had been isolated and removed from 15 rabbits at varying intervals after tissue injury was studied. In each instance CRP was synthesized at constant rates, for 3-8 h, without need for further stimulus. Rates of CRP synthesis by perfused livers, rose with increasing duration of tissue injury prior to isolation of the livers and correlated strongly with serum CRP levels attained by the time of sacrifice. CRP, synthesized by perfused livers at constant rates, indicates that the continuing increase in rate of CRP synthesis occurring in rabbits in vivo appears to depend on continuing exposure to factors of extrahepatic origin; the consequences of exposure to such factors do not persist after isolation of the organ. [CRP apparently plays a significant role in the inflammation immune response to tissue injury and complement activation.].