Comparative Virulence of NAD‐Dependent and NAD‐Independent Actinobacillus pleuropneumoniae Strains

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Abstract
The virulence of a NAD‐independent Actinobacillus pleuropneumoniae serotype 2 strain and NAD‐dependent serotype 2, 3 and 9 strains was compared under experimental conditions. Hysterectomy‐derived piglets were inoculated endobronchially with 50–500 cfu of these strains. All 23 piglets inoculated with the NAD‐dependent strains developed acute disease within 12 hours post inoculation. Twenty‐two of these piglets died within 24 hours after the first clinical signs. Three of nine piglets inoculated with the NAD‐independent strain did not develop clinical disease. In the other six piglets, disease signs were similar as in the piglets inoculated with the NAD‐dependent strains. No differences in clinical disease were observed between colostrum deprived piglets and piglets that obtained colostrum from a SPF sow.