Amplification Effect Observed in Interrelated Enzyme Systems after Irradiation

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Abstract
The effect of ionizing radiation on the over-all reaction rate of single- or multiple-enzyme systems was studied. In each experiment, 1 or 2 components were partially inactivated by [gamma]-irradiation before being added to the system. When 2 irradiated components were added to the system the magnitude of the change in the over-all reaction rate was a multiple or the sum of the rate changes produced by irradiation of each component alone. The possible role of this type of "amplification" on interrelated reactions subsequent to primary radiation events is discussed in relation to the development of observable injury in irradiated cells.