Study on Synthetic Methods of Trialkyl Phosphate Oxide and Its Extraction Behavior of Some Acids
- 1 February 1987
- journal article
- research article
- Published by Taylor & Francis in Separation Science and Technology
- Vol. 22 (2-3) , 315-323
- https://doi.org/10.1080/01496398708068954
Abstract
Trioctyl phosphine oxide (TOPO) is useful for the extraction of many inorganic and organic compounds. A mixed trialkyl phosphine oxide (TRPO) (where R1, R2, and R3 are different alkyl groups) is similar in property to TOPO. The total number of carbon atoms per molecule of TRPO ranges from 15 to 27. Three methods for synthesizing TRPO are described in this paper. When TRPO is synthesized from an alcohol mixture it is significantly cheaper than a single pure alcohol as required for the production of TOPO; tedious purification steps are eliminated. TRPO is a brown liquid which is very slightly soluble in water. Toxicological measurements of LD50, AMES test, hereditary and accumulative toxicity show that TRPO is safe for use in the extraction of some pharmaceutical and biochemical compounds. Examinations of IR and NMR show that the complex interaction of P=O bond of TRPO with extracted substances is the same as that of TOPO. The distribution coefficients of phosphoric acid, citric acid, malic acid, oxalic acid, and tartaric acid with TRPO are reported. The extraction of these acids is believed to proceed by neutral-complex mechanism.Keywords
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