6-Hydroxydopa Depletion of Brain Norepinephrine and the Facilitation of Aggressive Behavior
- 6 October 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 178 (4056) , 75-77
- https://doi.org/10.1126/science.178.4056.75
Abstract
A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system.Keywords
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