NEUROPEPTIDE Y AND NOREPINEPHRINE INJECTED INTO THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS ACTIVATE ENDOCRINE PANCREAS

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Abstract
Neuropeptide Y (NPY) or norepinephrine (NE) was injected into the paraventricular nucleus of the hypothalamus (PVN) of unanesthetized free-moving rats, and food intake and the plasma levels of glucose, insulin and glucagon were measured. Injection of NPY (1-5 .mu.g) or NE (40 nmol) elicited a large increase in food intake (4-9 g/h) with a latency of 3-7 min. Even when food was absent, injection of NPY produced an increase in plasma glucose, glucagon and insulin levels 10-30 min after injection. NE also produced a remarkable increase in plasma glucagon and glucose levels, while it had no effect on plasma insulin level. These results suggest that NPY as well as NE in the PVN play a role in hypothalamic control of endocrine pancreas.

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