DOPAMINERGIC ACTIVITY OF SOME APOMORPHINE ANALOGS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (1) , 89-106
Abstract
The dopaminergic activity of 10 apomorphine analogs was studied in rats lesioned unilaterally with 6-hydroxydopamine in the nigro-striatal system. N,N-dimethyl-5,6-dihydroxy-2-aminotetralin (M-7), N-methyl-5,6-dihydroxy-2-aminotetralin (M-8) and N,N-dimethyl-4,5-dihydroxy-2-aminoindan (DDAI) exhibited potent dopaminergic stimulant activity by causing the rat to turn to the unoperated side. The turning behavior of apomorphine, M-7, DDAI and d-amphetamine were antagonized by haloperidol. M-7 and DDAI also induced pecking in pigeons and their effects were also blocked by haloperidol. M-7, M-8 and DDAI are direct acting central dopaminergic agents.