Preparation and properties of FabIgG, a chimeric univalent antibody designed to attack tumour cells
- 1 January 1985
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 5 (10-11) , 991-998
- https://doi.org/10.1007/bf01119911
Abstract
In order to promote the killing of tumour cells by antibody a derivative has been synthesized in which Fab'γ from xenogeneic antibody is thioether-bonded to half-cystine on normal IgG of the species to be treated. The resulting entity, FabIgG, is obtained with about a 40% yield of the starting Fab'γ. Being univalent it evades antigenic modulation. It activates complement efficiently, is minimally immunogenic, and appears to be catabolized at the slow rate characteristic of autologous IgG.This publication has 16 references indexed in Scilit:
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