Low Renin Hypertension and the Adrenal Cortex

Abstract
THE concept that the adrenal cortex might be involved in the development of hypertension has been speculated upon by endocrinologists for approximately 60 years. In the early 1900's, Achard and Thiers1 described a patient with hypertension and marked hirsutism who at autopsy was found to have bilaterally enlarged adrenal glands. They implied that the hypertension and the hirsutism were due to some abnormality within the adrenal glands. This concept lay dormant for about 20 years, until Cushing2 reported the syndrome that is now named after him. Hypertension was a prominent part of this syndrome, and the implication was that the . . .

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