COMMON CHARACTERISTICS OF CYTOCHROME-P-450 SYSTEM INVOLVED IN 18BETA-HYDROXYLATION AND 11BETA-HYDROXYLATION OF DEOXYCORTICOSTERONE IN RAT ADRENALS
- 1 January 1977
- journal article
- research article
- Vol. 18 (5) , 592-603
Abstract
18- and 11.beta.-Hydroxylation of deoxycorticosterone and side chain cleavage of cholesterol were studied in mitochondria and submitochondrial reconstituted systems prepared from rat and bovine adrenals. A mass fragmentographic technique was used that allows determination of hydroxylation of exogenous and endogenous cholesterol. 18- and 11.beta.-Hydroxylation have similar properties. The binding site for deoxycorticosterone is similar or identical in the 2 hydroxylations. The possibility that the same specific type of cytochrome P-450 is responsible for 18- and 11.beta.-hydroxylation of deoxycorticosterone is discussed.This publication has 7 references indexed in Scilit:
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