The McCune–Albright Syndrome

Publisher Website
Google Scholar
Abstract
In 1937, McCune and Bruch1 and Albright and associates2 separately described an unusual syndrome characterized by polyostotic fibrous dysplasia, café au lait pigmentation, and in female patients, endocrine dysfunction with precocious puberty. Subsequent descriptions of this syndrome documented the occurrence of several other endocrine abnormalities, including hyperthyroidism, hypercortisolism, an excess of growth hormone, and hypophosphatemia. The triad of bone, skin, and endocrine abnormalities has come to constitute the classic McCune–Albright syndrome.The resemblance of the various components of the McCune–Albright syndrome to those of other, more common disorders has often invited comparison. The severity of the skeletal abnormalities varies widely. . . .