IN-VITRO STEROIDOGENESIS BY AN UNDIFFERENTIATED EMBRYONAL CELL SARCOMA OF THE OVARY

1 March 1969

journal article
Published by Bioscientifica in Journal of Endocrinology

Vol. 43 (3) , 437-444
https://doi.org/10.1677/joe.0.0430437

Abstract

Tritiated pregnenolone, 17α-hydroxypregnenolone, progesterone, 17α-hydroxyprogesterone, testosterone and androstenedione were incubated separately with homogenates from an undifferentiated embryonal cell sarcoma obtained from an 11-yr.-old girl. [³H]Pregnenolone and [³H]17α-hydroxypregnenolone were converted to [³H]oestradiol-17β in larger proportion than [³H]progesterone and [³H]17α-hydroxyprogesterone. The steroidogenesis in the sarcoma was very similar to that reported for the theca cells of the human ovarian follicle.

Keywords

SARCOMA
TESTOSTERONE
FOLLICLE
STEROIDOGENESIS
THECA
CONVERTED
UNDIFFERENTIATED EMBRYONAL
INCUBATED

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