INDUCTIVE EFFECTS OF TIADENOL (BIS(HYDROXYETHYLTHIO)-1,10 DECANE) ON HEPATIC MICROSOMAL-ENZYMES IN RATS
- 1 January 1983
- journal article
- research article
- Vol. 14 (2) , 171-182
Abstract
Male Wistar rats were treated with tiadenol, 200 mg/kg p.o. [orally] daily for 7 days. The administration of tiadenol markedly increased the activity of bilirubin glucuronosyl transferase in hepatic microsomes. Cytochrome P450 levels and ethoxycoumarin deethylase activity were more slightly increased. Electrophoresis of microsomal proteins showed the induction of a protein with a MW of .apprx. 72,000. Tiadenol alone only slightly affected the fatty acid composition of microsomal lecithins and cephalins. When given with phenobarbital, tiadenol modified the phenobarbital-induced changes in the fatty acid composition of microsomal lipids.This publication has 13 references indexed in Scilit:
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